Hennepin Healthcare is conducting a research study that will look at whether calcium, vasopressin, or both early in the course of treatment would help severely injured patients that lose a lot of blood survive their injuries.
The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) trial will include approximately 1,050 people aged 18 to 90. Patients who have traumatic injuries with loss of blood may be enrolled by participating emergency medical personnel during their transportation to the hospital or after arrival to Hennepin County Medical Center.
CAVALIER is an Exception from Informed Consent (EFIC) trial, meaning that, the trial requires performing a potentially life-saving intervention in people who are too injured to give permission. This study will look at treatment for patients who have a traumatic injury and have lost a lot of blood. These patients are too injured to give permission before receiving the study drug. Permission for continued participation will be obtained from patients once they are able, or from their family members, as soon as possible.
For more information about CAVALIER or to complete an anonymous survey on your thoughts about this EFIC study, please go to www.litesnetwork.org/cavalier. To see the CAVALIER press release in Spanish or Somali go to the Hennepin Healthcare Research Institute page.
This research is supported by DoD contract W81XWH-16-D-0024 W81XWH-22-F-0118. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the Department of the Army, Department of Defense, or the U.S. Government.
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Hennepin Healthcare is a nationally recognized system of care that includes HCMC, a Level I Adult Trauma Center and Level 1 Pediatric Trauma Center with the largest emergency department in Minnesota. The comprehensive academic medical center and public teaching hospital includes a 484-bed acute care hospital as well as primary care and specialty clinics located in downtown Minneapolis its surrounding communities.
